Illuminated by a great assortment of original illustrations, this remarkable book charts the step-by-step evolution of vertebrate blood coagulation. Intended for readers with a background in biological science, it is specifically targeted for those in the field of molecular evolution and researchers in the area of blood clotting. The orderly way in which gene duplications provided new genes for fine-tuning the system serves as a model for how complex physiological systems in general have evolved. The book includes suggestions for specific genetic engineering experiments that can be done to illustrate how molecular evolution works. An extensive glossary and guide to the current literature combine to make this book ideal for course use as well as for self-study.
Contents
Part I: Laying the Groundwork
Chapter 1: Blood Clotting in Humans
Chapter 2: Clotting Inhibitors and Fibrinolysis
Chapter 3: Localizing Clots
Chapter 4: Proteins and Domains
Chapter 5: Fibrinogen and Fibrin
Chapter 6: Animals, Their Proteins and Phylogenetics
Chapter 7: Gene Duplications
Chapter 8: Genomes
Part II: Searching Through Genomes
Chapter 9: Genomes of Fish with Jaws
Chapter 10: Lamprey Clotting Genes
Chapter 11: Contact Factors and Other Embellishments
Chapter 12: Protochordate Genomes
Chapter 13: How the System Began"
